AustralieFrV1, Main, Exploration, bibRecord, 002F59

Daclatasvir plus peginterferon and ribavirin is noninferior to peginterferon and ribavirin alone, and reduces the duration of treatment for HCV genotype 2 or 3 infection.

Identifieur interne : 002F59 ( Main/Exploration ); précédent : 002F58; suivant : 002F60

Daclatasvir plus peginterferon and ribavirin is noninferior to peginterferon and ribavirin alone, and reduces the duration of treatment for HCV genotype 2 or 3 infection.

Auteurs : Gregory J. Dore [Australie] ; Eric Lawitz [États-Unis] ; Christophe Hézode [France] ; Stephen D. Shafran [Canada] ; Alnoor Ramji [Canada] ; Harvey A. Tatum [États-Unis] ; Gloria Taliani [Italie] ; Albert Tran [France] ; Maurizia R. Brunetto [Italie] ; Serena Zaltron [Italie] ; Simone I. Strasser [Australie] ; Nina Weis [Danemark] ; Wayne Ghesquiere [Canada] ; Samuel S. Lee [Canada] ; Dominique Larrey [France] ; Stanislas Pol [France] ; Hugh Harley [Australie] ; Jacob George [Australie] ; Scott K. Fung [Canada] ; Victor De Lédinghen [France] ; Peggy Hagens [Belgique] ; Fiona Mcphee [États-Unis] ; Dennis Hernandez [États-Unis] ; David Cohen [États-Unis] ; Elizabeth Cooney [États-Unis] ; Stephanie Noviello [États-Unis] ; Eric A. Hughes [États-Unis]

Source :

Gastroenterology [ 1528-0012 ] ; 2015.

RBID : pubmed:25311593

Descripteurs français

KwdFr :
- ARN viral (analyse), Adolescent, Adulte, Adulte d'âge moyen, Antiviraux (usage thérapeutique), Association de médicaments, Femelle, Génotype, Hepacivirus (), Humains, Hépatite C chronique (traitement médicamenteux), Hépatite C chronique (virologie), Imidazoles (administration et posologie), Imidazoles (effets indésirables), Interféron alpha (administration et posologie), Interféron alpha (effets indésirables), Interféron alpha (usage thérapeutique), Mâle, Méthode en double aveugle, Polyéthylène glycols (administration et posologie), Polyéthylène glycols (effets indésirables), Polyéthylène glycols (usage thérapeutique), Protéines recombinantes (administration et posologie), Protéines recombinantes (effets indésirables), Protéines recombinantes (usage thérapeutique), Ribavirine (administration et posologie), Ribavirine (effets indésirables), Ribavirine (usage thérapeutique), Sujet âgé.
MESH :
- administration et posologie : Imidazoles, Interféron alpha, Polyéthylène glycols, Protéines recombinantes, Ribavirine.
- analyse : ARN viral.
- effets indésirables : Imidazoles, Interféron alpha, Polyéthylène glycols, Protéines recombinantes, Ribavirine.
- traitement médicamenteux : Hépatite C chronique.
- usage thérapeutique : Antiviraux, Interféron alpha, Polyéthylène glycols, Protéines recombinantes, Ribavirine.
- virologie : Hépatite C chronique.
- Adolescent, Adulte, Adulte d'âge moyen, Association de médicaments, Femelle, Génotype, Hepacivirus, Humains, Mâle, Méthode en double aveugle, Sujet âgé.

English descriptors

KwdEn :
- Adolescent, Adult, Aged, Antiviral Agents (therapeutic use), Double-Blind Method, Drug Therapy, Combination, Female, Genotype, Hepacivirus (classification), Hepatitis C, Chronic (drug therapy), Hepatitis C, Chronic (virology), Humans, Imidazoles (administration & dosage), Imidazoles (adverse effects), Interferon-alpha (administration & dosage), Interferon-alpha (adverse effects), Interferon-alpha (therapeutic use), Male, Middle Aged, Polyethylene Glycols (administration & dosage), Polyethylene Glycols (adverse effects), Polyethylene Glycols (therapeutic use), RNA, Viral (analysis), Recombinant Proteins (administration & dosage), Recombinant Proteins (adverse effects), Recombinant Proteins (therapeutic use), Ribavirin (administration & dosage), Ribavirin (adverse effects), Ribavirin (therapeutic use).
MESH :
- chemical , administration & dosage : Imidazoles, Interferon-alpha, Polyethylene Glycols, Recombinant Proteins, Ribavirin.
- chemical , adverse effects : Imidazoles, Interferon-alpha, Polyethylene Glycols, Recombinant Proteins, Ribavirin.
- chemical , analysis : RNA, Viral.
- chemical , therapeutic use : Antiviral Agents, Interferon-alpha, Polyethylene Glycols, Recombinant Proteins, Ribavirin.
- classification : Hepacivirus.
- drug therapy : Hepatitis C, Chronic.
- virology : Hepatitis C, Chronic.
- Adolescent, Adult, Aged, Double-Blind Method, Drug Therapy, Combination, Female, Genotype, Humans, Male, Middle Aged.

Abstract

Twenty-four weeks of treatment with peginterferon and ribavirin for chronic hepatitis C virus (HCV) genotype 2 or 3 infection produces a sustained virologic response (SVR) in 70%-80% of patients. We performed a randomized, double-blind, phase 2b study to assess whether adding daclatasvir, a nonstructural protein 5A (NS5A) inhibitor that is active against these genotypes, improves efficacy and shortens therapy.

DOI: 10.1053/j.gastro.2014.10.007
PubMed: 25311593

Affiliations:

Le document en format XML

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<author><name sortKey="Weis, Nina" sort="Weis, Nina" uniqKey="Weis N" first="Nina" last="Weis">Nina Weis</name>
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<author><name sortKey="Ghesquiere, Wayne" sort="Ghesquiere, Wayne" uniqKey="Ghesquiere W" first="Wayne" last="Ghesquiere">Wayne Ghesquiere</name>
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<author><name sortKey="Lee, Samuel S" sort="Lee, Samuel S" uniqKey="Lee S" first="Samuel S" last="Lee">Samuel S. Lee</name>
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<author><name sortKey="Larrey, Dominique" sort="Larrey, Dominique" uniqKey="Larrey D" first="Dominique" last="Larrey">Dominique Larrey</name>
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<author><name sortKey="Pol, Stanislas" sort="Pol, Stanislas" uniqKey="Pol S" first="Stanislas" last="Pol">Stanislas Pol</name>
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<author><name sortKey="Harley, Hugh" sort="Harley, Hugh" uniqKey="Harley H" first="Hugh" last="Harley">Hugh Harley</name>
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<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
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<author><name sortKey="George, Jacob" sort="George, Jacob" uniqKey="George J" first="Jacob" last="George">Jacob George</name>
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<author><name sortKey="De Ledinghen, Victor" sort="De Ledinghen, Victor" uniqKey="De Ledinghen V" first="Victor" last="De Lédinghen">Victor De Lédinghen</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Hepatology and Gastroenterology, Hôpital Haut-Lévêque, Pessac</wicri:regionArea>
<wicri:noRegion>Pessac</wicri:noRegion>
<wicri:noRegion>Pessac</wicri:noRegion>
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<author><name sortKey="Hagens, Peggy" sort="Hagens, Peggy" uniqKey="Hagens P" first="Peggy" last="Hagens">Peggy Hagens</name>
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<wicri:regionArea>Research and Development, Bristol-Myers Squibb, Braine-l'Alleud</wicri:regionArea>
<wicri:noRegion>Braine-l'Alleud</wicri:noRegion>
</affiliation>
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<author><name sortKey="Mcphee, Fiona" sort="Mcphee, Fiona" uniqKey="Mcphee F" first="Fiona" last="Mcphee">Fiona Mcphee</name>
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</placeName>
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</affiliation>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Research and Development, Bristol-Myers Squibb, Wallingford</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cohen, David" sort="Cohen, David" uniqKey="Cohen D" first="David" last="Cohen">David Cohen</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Research and Development, Bristol-Myers Squibb, Wallingford</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cooney, Elizabeth" sort="Cooney, Elizabeth" uniqKey="Cooney E" first="Elizabeth" last="Cooney">Elizabeth Cooney</name>
<affiliation wicri:level="2"><nlm:affiliation>Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Research and Development, Bristol-Myers Squibb, Wallingford</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Noviello, Stephanie" sort="Noviello, Stephanie" uniqKey="Noviello S" first="Stephanie" last="Noviello">Stephanie Noviello</name>
<affiliation wicri:level="2"><nlm:affiliation>Research and Development, Bristol-Myers Squibb, Princeton, New Jersey.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Research and Development, Bristol-Myers Squibb, Princeton</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hughes, Eric A" sort="Hughes, Eric A" uniqKey="Hughes E" first="Eric A" last="Hughes">Eric A. Hughes</name>
<affiliation wicri:level="2"><nlm:affiliation>Research and Development, Bristol-Myers Squibb, Princeton, New Jersey.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Research and Development, Bristol-Myers Squibb, Princeton</wicri:cityArea>
</affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Daclatasvir plus peginterferon and ribavirin is noninferior to peginterferon and ribavirin alone, and reduces the duration of treatment for HCV genotype 2 or 3 infection.</title>
<author><name sortKey="Dore, Gregory J" sort="Dore, Gregory J" uniqKey="Dore G" first="Gregory J" last="Dore">Gregory J. Dore</name>
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<wicri:regionArea>Kirby Institute, University of New South Wales and St Vincent's Hospital, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
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<author><name sortKey="Lawitz, Eric" sort="Lawitz, Eric" uniqKey="Lawitz E" first="Eric" last="Lawitz">Eric Lawitz</name>
<affiliation wicri:level="2"><nlm:affiliation>The Texas Liver Institute, University of Texas Health Science Center, San Antonio, Texas.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>The Texas Liver Institute, University of Texas Health Science Center, San Antonio</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hezode, Christophe" sort="Hezode, Christophe" uniqKey="Hezode C" first="Christophe" last="Hézode">Christophe Hézode</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Hepatology, Hôpital Henri Mondor, Créteil, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Hepatology, Hôpital Henri Mondor, Créteil</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Créteil</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shafran, Stephen D" sort="Shafran, Stephen D" uniqKey="Shafran S" first="Stephen D" last="Shafran">Stephen D. Shafran</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Infectious Diseases, University of Alberta, Edmonton, Alberta, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Infectious Diseases, University of Alberta, Edmonton, Alberta</wicri:regionArea>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ramji, Alnoor" sort="Ramji, Alnoor" uniqKey="Ramji A" first="Alnoor" last="Ramji">Alnoor Ramji</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, University of British Columbia, Vancouver, British Columbia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Gastroenterology, University of British Columbia, Vancouver, British Columbia</wicri:regionArea>
<wicri:noRegion>British Columbia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tatum, Harvey A" sort="Tatum, Harvey A" uniqKey="Tatum H" first="Harvey A" last="Tatum">Harvey A. Tatum</name>
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<country xml:lang="fr">Italie</country>
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<author><name sortKey="Weis, Nina" sort="Weis, Nina" uniqKey="Weis N" first="Nina" last="Weis">Nina Weis</name>
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<country xml:lang="fr">Danemark</country>
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</author>
<author><name sortKey="Ghesquiere, Wayne" sort="Ghesquiere, Wayne" uniqKey="Ghesquiere W" first="Wayne" last="Ghesquiere">Wayne Ghesquiere</name>
<affiliation wicri:level="1"><nlm:affiliation>Vancouver Island Health Authority and University of British Columbia, Victoria, British Columbia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
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<author><name sortKey="Lee, Samuel S" sort="Lee, Samuel S" uniqKey="Lee S" first="Samuel S" last="Lee">Samuel S. Lee</name>
<affiliation wicri:level="4"><nlm:affiliation>Liver Unit, University of Calgary, Calgary, Alberta, Canada.</nlm:affiliation>
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<wicri:regionArea>Liver Unit, University of Calgary, Calgary, Alberta</wicri:regionArea>
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<author><name sortKey="Larrey, Dominique" sort="Larrey, Dominique" uniqKey="Larrey D" first="Dominique" last="Larrey">Dominique Larrey</name>
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<author><name sortKey="Pol, Stanislas" sort="Pol, Stanislas" uniqKey="Pol S" first="Stanislas" last="Pol">Stanislas Pol</name>
<affiliation wicri:level="4"><nlm:affiliation>Université Paris Descartes, Unité d'Hépatologie, Hôpital Cochin, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<author><name sortKey="Harley, Hugh" sort="Harley, Hugh" uniqKey="Harley H" first="Hugh" last="Harley">Hugh Harley</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, Royal Adelaide Hospital and University of Adelaide, Adelaide, Australia.</nlm:affiliation>
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<wicri:regionArea>Department of Gastroenterology and Hepatology, Royal Adelaide Hospital and University of Adelaide, Adelaide</wicri:regionArea>
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</author>
<author><name sortKey="George, Jacob" sort="George, Jacob" uniqKey="George J" first="Jacob" last="George">Jacob George</name>
<affiliation wicri:level="3"><nlm:affiliation>Storr Liver Unit, Westmead Millennium Institute, University of Sydney and Westmead Hospital, Sydney, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Storr Liver Unit, Westmead Millennium Institute, University of Sydney and Westmead Hospital, Sydney</wicri:regionArea>
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<region type="état">Nouvelle-Galles du Sud</region>
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<author><name sortKey="Fung, Scott K" sort="Fung, Scott K" uniqKey="Fung S" first="Scott K" last="Fung">Scott K. Fung</name>
<affiliation wicri:level="1"><nlm:affiliation>Divisions of Gastroenterology and General Internal Medicine, Toronto General Hospital, Toronto, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Divisions of Gastroenterology and General Internal Medicine, Toronto General Hospital, Toronto, Ontario</wicri:regionArea>
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</author>
<author><name sortKey="De Ledinghen, Victor" sort="De Ledinghen, Victor" uniqKey="De Ledinghen V" first="Victor" last="De Lédinghen">Victor De Lédinghen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Hepatology and Gastroenterology, Hôpital Haut-Lévêque, Pessac, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Hepatology and Gastroenterology, Hôpital Haut-Lévêque, Pessac</wicri:regionArea>
<wicri:noRegion>Pessac</wicri:noRegion>
<wicri:noRegion>Pessac</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hagens, Peggy" sort="Hagens, Peggy" uniqKey="Hagens P" first="Peggy" last="Hagens">Peggy Hagens</name>
<affiliation wicri:level="1"><nlm:affiliation>Research and Development, Bristol-Myers Squibb, Braine-l'Alleud, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Research and Development, Bristol-Myers Squibb, Braine-l'Alleud</wicri:regionArea>
<wicri:noRegion>Braine-l'Alleud</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcphee, Fiona" sort="Mcphee, Fiona" uniqKey="Mcphee F" first="Fiona" last="Mcphee">Fiona Mcphee</name>
<affiliation wicri:level="2"><nlm:affiliation>Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Research and Development, Bristol-Myers Squibb, Wallingford</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hernandez, Dennis" sort="Hernandez, Dennis" uniqKey="Hernandez D" first="Dennis" last="Hernandez">Dennis Hernandez</name>
<affiliation wicri:level="2"><nlm:affiliation>Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
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</affiliation>
</author>
<author><name sortKey="Cohen, David" sort="Cohen, David" uniqKey="Cohen D" first="David" last="Cohen">David Cohen</name>
<affiliation wicri:level="2"><nlm:affiliation>Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Connecticut</region>
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</affiliation>
</author>
<author><name sortKey="Cooney, Elizabeth" sort="Cooney, Elizabeth" uniqKey="Cooney E" first="Elizabeth" last="Cooney">Elizabeth Cooney</name>
<affiliation wicri:level="2"><nlm:affiliation>Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
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</affiliation>
</author>
<author><name sortKey="Noviello, Stephanie" sort="Noviello, Stephanie" uniqKey="Noviello S" first="Stephanie" last="Noviello">Stephanie Noviello</name>
<affiliation wicri:level="2"><nlm:affiliation>Research and Development, Bristol-Myers Squibb, Princeton, New Jersey.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Research and Development, Bristol-Myers Squibb, Princeton</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hughes, Eric A" sort="Hughes, Eric A" uniqKey="Hughes E" first="Eric A" last="Hughes">Eric A. Hughes</name>
<affiliation wicri:level="2"><nlm:affiliation>Research and Development, Bristol-Myers Squibb, Princeton, New Jersey.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Research and Development, Bristol-Myers Squibb, Princeton</wicri:cityArea>
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<series><title level="j">Gastroenterology</title>
<idno type="eISSN">1528-0012</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
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<term>Adult</term>
<term>Aged</term>
<term>Antiviral Agents (therapeutic use)</term>
<term>Double-Blind Method</term>
<term>Drug Therapy, Combination</term>
<term>Female</term>
<term>Genotype</term>
<term>Hepacivirus (classification)</term>
<term>Hepatitis C, Chronic (drug therapy)</term>
<term>Hepatitis C, Chronic (virology)</term>
<term>Humans</term>
<term>Imidazoles (administration & dosage)</term>
<term>Imidazoles (adverse effects)</term>
<term>Interferon-alpha (administration & dosage)</term>
<term>Interferon-alpha (adverse effects)</term>
<term>Interferon-alpha (therapeutic use)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Polyethylene Glycols (administration & dosage)</term>
<term>Polyethylene Glycols (adverse effects)</term>
<term>Polyethylene Glycols (therapeutic use)</term>
<term>RNA, Viral (analysis)</term>
<term>Recombinant Proteins (administration & dosage)</term>
<term>Recombinant Proteins (adverse effects)</term>
<term>Recombinant Proteins (therapeutic use)</term>
<term>Ribavirin (administration & dosage)</term>
<term>Ribavirin (adverse effects)</term>
<term>Ribavirin (therapeutic use)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (analyse)</term>
<term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Antiviraux (usage thérapeutique)</term>
<term>Association de médicaments</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Hepacivirus ()</term>
<term>Humains</term>
<term>Hépatite C chronique (traitement médicamenteux)</term>
<term>Hépatite C chronique (virologie)</term>
<term>Imidazoles (administration et posologie)</term>
<term>Imidazoles (effets indésirables)</term>
<term>Interféron alpha (administration et posologie)</term>
<term>Interféron alpha (effets indésirables)</term>
<term>Interféron alpha (usage thérapeutique)</term>
<term>Mâle</term>
<term>Méthode en double aveugle</term>
<term>Polyéthylène glycols (administration et posologie)</term>
<term>Polyéthylène glycols (effets indésirables)</term>
<term>Polyéthylène glycols (usage thérapeutique)</term>
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<term>Protéines recombinantes (effets indésirables)</term>
<term>Protéines recombinantes (usage thérapeutique)</term>
<term>Ribavirine (administration et posologie)</term>
<term>Ribavirine (effets indésirables)</term>
<term>Ribavirine (usage thérapeutique)</term>
<term>Sujet âgé</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Imidazoles</term>
<term>Interferon-alpha</term>
<term>Polyethylene Glycols</term>
<term>Recombinant Proteins</term>
<term>Ribavirin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Imidazoles</term>
<term>Interferon-alpha</term>
<term>Polyethylene Glycols</term>
<term>Recombinant Proteins</term>
<term>Ribavirin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term>
<term>Interferon-alpha</term>
<term>Polyethylene Glycols</term>
<term>Recombinant Proteins</term>
<term>Ribavirin</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Imidazoles</term>
<term>Interféron alpha</term>
<term>Polyéthylène glycols</term>
<term>Protéines recombinantes</term>
<term>Ribavirine</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ARN viral</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Hepacivirus</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hepatitis C, Chronic</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Imidazoles</term>
<term>Interféron alpha</term>
<term>Polyéthylène glycols</term>
<term>Protéines recombinantes</term>
<term>Ribavirine</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Hépatite C chronique</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term>
<term>Interféron alpha</term>
<term>Polyéthylène glycols</term>
<term>Protéines recombinantes</term>
<term>Ribavirine</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Hépatite C chronique</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Hepatitis C, Chronic</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Double-Blind Method</term>
<term>Drug Therapy, Combination</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Association de médicaments</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Hepacivirus</term>
<term>Humains</term>
<term>Mâle</term>
<term>Méthode en double aveugle</term>
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<front><div type="abstract" xml:lang="en">Twenty-four weeks of treatment with peginterferon and ribavirin for chronic hepatitis C virus (HCV) genotype 2 or 3 infection produces a sustained virologic response (SVR) in 70%-80% of patients. We performed a randomized, double-blind, phase 2b study to assess whether adding daclatasvir, a nonstructural protein 5A (NS5A) inhibitor that is active against these genotypes, improves efficacy and shortens therapy.</div>
</front>
</TEI>
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<li>États-Unis</li>
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<country name="Belgique"><noRegion><name sortKey="Hagens, Peggy" sort="Hagens, Peggy" uniqKey="Hagens P" first="Peggy" last="Hagens">Peggy Hagens</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:25311593
   |texte=   Daclatasvir plus peginterferon and ribavirin is noninferior to peginterferon and ribavirin alone, and reduces the duration of treatment for HCV genotype 2 or 3 infection.
}}

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       | NlmPubMed2Wicri -a AustralieFrV1

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Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

Daclatasvir plus peginterferon and ribavirin is noninferior to peginterferon and ribavirin alone, and reduces the duration of treatment for HCV genotype 2 or 3 infection.

Daclatasvir plus peginterferon and ribavirin is noninferior to peginterferon and ribavirin alone, and reduces the duration of treatment for HCV genotype 2 or 3 infection.

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	Serveur d'exploration sur les relations entre la France et l'Australie
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